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Among the four, three new interfacial salt bridges (Figures 3 and 4) were found to be formed due to the missense mutations introduced into semaglutides backbone (including in particular L23B R), whereas only one interfacial salt bridge (yellow row in Table 4) was found to be formed and the same as the salt bridge (Table 1) identified in PDB entry 4ZGM [24, 35]

Wegovy commonly causes nausea, vomiting, diarrhoea, constipation, and abdominal discomfort, especially when starting treatment or increasing doses

Zero side effects perhaps the most important finding for daily-use products

Further research is needed to establish its effectiveness definitively