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The expression and activity of these markers were associated with DE caused by hormone deficits, systemic autoimmune diseases, microelement deficiency, pollution, and ocular surface disease not necessarily related to systemic conditions (Wakamatsu et al., 2008

The low detection accuracy of in vivo imaging, caused by interference from free iron, parallels the translational paradox seen in clinical trials of iron chelators such as deferoxamineeffective in animals but ineffective in humansrevealing that a coordinated validation system linking molecular targets, imaging evaluation, and clinical efficacy is still lacking