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About this article Cite this article Al-Hakeim, H.K., Al-Rubaye, H.T., Al-Hadrawi, D.S

While enhanced alcohol metabolism may seem protective, elevated CYP2E1 accelerates ethanol oxidation, resulting in higher acetaldehyde production and excessive reactive oxygen species (ROS) generation, including hydroxyethyl radicals, superoxide anions, and hydroxyl radicals [27, 28]