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Mitochondria, the cellular organelles known as the powerhouses of the cell, are central to this discussion

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Before degradation or elongation can take place, FFAs need to be activated to acyl-coenzyme A (-CoA) esters by one of a variety of different chain-length-specific synthetases localized in distinct subcellular compartments [3]

However, like other TKIs, lenvatinib often causes adverse drug reactions such as hypertension, diarrhea, proteinuria, and fatigue, which may lead to dose interruption or discontinuation (Kudo et al., 2018), (Kim et al., 2021)