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[1] [2] This triple-action mechanism promotes reductions in body weight by suppressing appetite, slowing gastric emptying, and based on early human data may increase energy expenditure, though this effect requires further confirmation

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Furthermore, a significant reduction in proteasome-mediated degradation of oxidized proteins in brains from MCI and AD subjects was associated with the increase of ox-PTMs such as carbonylation, HNE modification, and neuroprostane conjugation, thereby confirming a role for OS as a contributing factor (354)