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At the same time, Nrf2 is also a crucial regulatory factor for maintaining oxidative homeostasis in oxidative damage induced by the ROS production factor, NADPH oxidase 4 (NOX4)

One of the downstream targets of AMPK, rapamycin (mTOR), plays a role in the apoptosis and autophagy of SCs in the development of DPN disease (69), but the exact mechanism remains to be further clarified