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A recent study reported that leptin levels peaked around 05:00, decreased between 12:00 and 17:00, and then increased again between 20:00 and 06:00 [1, 55]

however, it should be mentioned that coexisting NP and other types of pains (such as nociceptive pain) can make difficult a reliable distinction (Treede et al., 2008

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While that may sound destabilizing, it points to a conformational shift in DNA duplex architecture that could facilitate transcription while preventing hardening of the genome that often accompanies age and oxidative stress [37]