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However, ARS induced ROS-dependent apoptosis in HeLa and A549 cell lines but ROS-independent apoptosis in HepG2 cells

Eye sign * KayserFleischer rings (brownish rings around the cornea) How its diagnosed * Serum ceruloplasmin * 24-hour urinary copper * Liver copper content (biopsy) * Slit-lamp exam KayserFleischer rings * Genetic testing (ATP7B mutation) Treatment (lifelong) The goal is to remove excess copper and prevent accumulation: 1

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Furthermore, the combination treatment enhanced PPAR expression, which improved lipid partitioning and encouraged adipose tissue remodeling, and raised GLUT2, which improved hepatic glucose uptake and insulin responsiveness