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TRPM2 channel in microglia as a new player in neuroinflammation associated with a spectrum of central nervous system pathologies

Consequently, the search for new therapies has focused on targets, particularly surface proteins that are preferentially present or overexpressed on cancer cells compared to normal cells

Abbreviations ABC: ATP-binding cassette ADM: Adrenomedullin ADC: Antibodydrug conjugate APC: Antigen presenting cell CAF: Cancer-associated fibroblast CBP: Carboplatin CSC: Cancer stem cell DDR: DNA damage response DFS: Disease-free survival DTP: Drug-tolerant persister ECM: Extracellular matrix EMT: Epithelialmesenchymal transition EOC: Epithelial ovarian cancer FTE: Fallopian tube epithelium GSH: Glutathione GST: Glutathione-S-transferase HGSOC: High-grade serous ovarian cancer HRR: Homologous recombination repair IMC: Imaging mass cytometry MC: Mesothelial cell MMR: Mismatch repair MT: Metallothionein NER: Nucleotide excision repair OXPHOS: Oxidative phosphorylation PARP: Poly(ADP-ribose) polymerase PDO: Patient-derived organoid PFS: Progression-free survival PUFA: Polyunsaturated fatty acid scRNA-seq: Single-cell RNA sequencing TAM: Tumor-associated macrophage TEC: Tumor endothelial cell TME: Tumor microenvironment TSP: Tumorstroma proportion References Matulonis UA, Sood AK, Fallowfield L, Howitt BE, Sehouli J, Karlan BY