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Bone microstructure: OVX control group: The number of bone trabeculae decreased by 30%, the thickness decreased by 25%, and the gap increased by 40%

They also play a role in maintaining physiological homeostasis, such as cognition, blood pressure, feeding behavior, water balance, glucose metabolism, pain, and response to stress [7]

For each assay, established enzyme specific inhibitors were included as positive controls for enzyme function and assay reproducibility

Scientific References (External Links) Nature Chemical Biology: Small molecule inhibitors of nicotinamide N-methyltransferase View Study Biochemical Pharmacology: Nicotinamide N-methyltransferase: A promising target for treating metabolic disorders View Study FASEB Journal: Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity in mice View Study Journal of Biological Chemistry: Inhibition of nicotinamide N-methyltransferase in vivo regulates cellular energy metabolism View Study