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621 Obesity, metabolic syndrome, diet, lifestyle, genetics, and environmental factors contribute to their development

Methods Female C57BL/6 mice were orally administered letrozole (LE) to induce PCOS and then randomly divided into groups receiving daily oral administration of 160 mg/kg NAC (PCOS + NAC group), 200 mg/kg metformin (PCOS + Met group), or 0.5% carboxymethyl cellulose (drug solvent) (pure PCOS group) for 12 days

Condensin-mediated genomic contacts are thought to arise through loop extrusion and diffusion capture mechanisms 40,41,42

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