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Similarly, a study focusing on CLOCK-related circadian regulators in nurses, found that hypermethylation in BMAL1 gene bodies was associated with working 3 consecutive NS per week, suggesting possible epigenetic silencing affecting CLOCK transcriptional activity

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Factors such as sitting time (Nogueira Silva Lima et al., 2021), high-calorie diet (Nogueira Silva Lima et al., 2021), sleep disturbance (Saner et al., 2021), and alcohol abuse (Wang et al., 2010) and factors that are hardly evitable such as environmental pollution (Grytting et al., 2022), light pollution (Grytting et al., 2022) diesel exhaust and the use of multiple medicines, including NAISDs (Tang et al., 2022), can produce a state of low-grade inflammation (LGI) associated with many chronic diseases (de Punder and Pruimboom, 2015a)

Acetyltransferase activity toward alkyl cysteine S -conjugates was detected in rat liver slices by Barnsley et al