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Cells were allowed to migrate from upper chamber (5% FBS) towards lower chamber which has 10% FBS

This includes depletion of biogenic amines, oxidative stress, depressive symptoms, and musculoskeletal pain without evident tissue damage, mirroring the clinical observations in FM patients [15]

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Notably, currently available therapies for RA, such as cytokine (TNF and IL-6) blockers or inhibitors of the JAK-STAT pathway 43 , exclusively tackle the inflammatory phase of the disease but do not interfere with the underlying processes that initiate the onset of arthritis and therefore often need to be given life-long 44