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In COVID-19 patients, an increase in inflammatory cytokines, such as interleukin 6 (IL-6), IL-2, IL-7, IL-10, granulocyte colony-stimulating factor (GCSF), interferon -induced protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP1), macrophage inflammatory protein 1-alpha (MIP1A), and tumor necrosis factor (TNF-), is observed which is called cytokine storm [5]

Diagnostic approach A thorough enquiry and physical examination should be performed for a basic evaluation, with an artificially induced erection to measure and document the degree of curvature, as well as document the fibrous plaque by ultrasound scan, if such procedure is available

The perinatal disease is the most severe form and is invariably fatal [34]

The Serum GC-MS and isotopically quantified serum metabolites (UPLCMS/MS) that have been used in this study are deposited in MassIVE with accession numbers MSV000088042 [ and MSV000088043 [ respectively