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Any reference to biological activity or potential effects is based solely on preclinical or in vitro findings and should not be interpreted as validated clinical outcomes

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Arch Biochem Biophys 2007;459:2739 [DOI] [PubMed] [Google Scholar] 62.Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, Valverde AM, Iwawaki T, Nahmias Y, Xavier R, Chung RT, Tirosh B, Shibolet O.CHOP is a critical regulator of acetaminophen-induced hepatotoxicity

Since some db/db mice succumbed to this treatment probably due to RIF toxicity at 16 mg/kg, we reduced the dose to 8 mg/kg and treated the animals 3 times weekly through oral gavage from day-4 onwards until 8 weeks post-infection