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Motor symptoms are also the most recognizable features, primarily including tremors, stiffness, motor dysfunction, and abnormal gait (Bloem et al., 2021)

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doi: 10.1111/j.1472-765X.2006.02062.x 394 SongLZhangFYuJWeiCHanQMengX

Abnormal iron metabolism may cause iron accumulation in various tissues, including the brain, liver and pancreas, potentially inducing neurodegenerative changes such as neuronal loss, gliosis and mitochondrial dysfunction, which may clinically manifest as ataxia, dystonia and dementia (23)