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In general, plants own very competent enzymatic [catalase (CAT), monodehydroascorbate reductase (MDHAR), superoxide dismutase (SOD), ascorbate peroxidase (APX), glutathione reductase (GR), dehydroascorbate reductase (DHAR), guaiacol peroxidase (GPX)] and non-enzymatic [glutathione (GSH), ascorbic acid (AsA), carotenoids, alkaloids, phenolic compounds as well as non-proteinaceous amino acids] antioxidative defensive systems which act in collaboration to regulate the problems of unrestrained oxidation and ultimately shield the plant cells from oxidants injury by scavenging these toxic ROS [11]

In summary, these natural products achieve multi-level comprehensive intervention in viral pneumonia models, from inhibiting viral replication and alleviating the release of inflammatory factors to regulating oxidative stress and tissue protection, by synergistically inhibiting PI3K/Akt and its cross-signaling axes, such as Nrf2, NF-B, NLRP3, establishing a natural drug action mechanism centered on integrated regulation of signaling pathways, providing theoretical support for the subsequent development of multi-target anti-inflammatory and antiviral drugs

to scavenge a number of free radicals

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