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Source: Moosmann, B., Roth, N

BRB disruption is a primary pathogenic mechanism of DR and the key factor driving DR progression from non-proliferative DR (NPDR) to proliferative DR (PDR)

M.ChowT.GarakianJ.VintersH

This relies on the activation of signaling pathways upon the recognition of Pathogen-Associated Molecular Patterns (PAMPs) on bacteria or their Outer Membrane Vesicles (OMVs), mainly Toll-Like Receptors-4 (TLR4) and TLR2 signaling mediated by LOS (Christodoulides, 2021) and PorB recognition (Toussi et al., 2016), respectively