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Genetic alterations that involve mutations in oncogenes and/or tumor suppressor genes lead to deregulated signaling pathways and consequently to the aberrant expression of transcription factors, enzymes, transporters, proteins (nuclear and cytoplasmic), and regulatory molecules of glucose metabolism (Lo Presti et al., 2020

The gut-lung axis: protozoa join the party

Notch is an essential upstream regulator of NF-B and is relevant for survival of Hodgkin and ReedSternberg cells

However, it should be noted that the expression of a methylated gene can be increased when either the coding sequence is hypermethylated or the promoter or transcriptional start site is hypomethylated[130]