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High-salt diet is an important factor for hypertension, which can deplete Lactobacillus in mice (108), while candesartan can counteract the decrease of Lactobacillus caused by hypertension, and candesartan treatment also increases the intestinal expression of genes encoding tight junction proteins (such as zonula occludens, occludin, and claudin-1), improving increased intestinal permeability caused by hypertension and preventing gut microbiota translocation (105)

The administration of kombucha tea via gavage at doses of 1 and 2 ml/kg per day was conducted for 2 weeks before the induction of transient global cerebral ischemia

concentrations drop by more than half between age 20 and 60

Manganese homeostasis in the nervous system