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Although Luxturna is approved for use in correcting RPE65 -induced retinal degeneration, only 12% of RP patients and 616% of Leber congenital amaurosis (LCA) patients have mutations that are treatable using this approach [36, 37]

As previously observed, the NAC complex was anchored to the ribosome via the NACB N-terminal alpha-helix hooked to ribosomal protein eL22 which tethers the globular domain of NAC (beta-sandwich) in proximity to the peptide exit tunnel, essentially as reported before (Fig