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Furthermore, ([ 11 C]( R )-PK11195)-based positron emission tomography (PET) has revealed a higher density of activated microglia in the midbrain and putamen of early PD patients (59, 60), which correlated with decreased activity of dopamine transporter ligands ([ 11 C] CFT)

However, a review of recent studies indicates that this is soon to change as more clinicians become aware of the unique advantages of nasal delivery of peptides and other therapeutics