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Importantly, NAD+ is only one part of a complex biological system

The blind-loop syndrome may produce deficiency of Vitamin B12 or folate

The rationale is mechanistic non-overlap: rather than two compounds acting through the same pathway with redundant effects, BPC-157 and TB-500 engage distinct targets the former operating through nitric-oxide-pathway and VEGFR2 modulation, the latter through actin-cytoskeleton regulation