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As with social use, ecstasy abuse can quickly lead to tolerance and dependence, where you experience unpleasant symptoms if you stop taking the drug

Clin Neuropathol 29: 271288, 2010

Thus, the variant alleles are recessive, and homozygosity for the variant alleles confers a relative lack of response to anti-leukotriene therapy in approximately 5% to 6% of subjects with asthma