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I.GaoG.WidmerJ.MichellB

Moran et al., 2002

Lastly, in contrast to GLO1, we found GLO2 protein levels to be downregulated and its precursor sLG to be upregulated by hypoxia in lung cancer cells, suggesting that hypoxic cells need to detoxify MG either by alternative routes 47,70 or perhaps they rather accumulate the nontoxic intermediate sLG than producing higher levels of D-lactate, which would further increase acidification next to the already upregulated anaerobic L-lactate production from pyruvate

(11) reported the first randomized, prospective and controlled clinical trial for treatment-intractable childhood epilepsy in which 3 month administration of a KD resulted in significant reduction in seizure frequency