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A small number of cancers (basal cell carcinoma, breast cancer, malignant melanoma, lipoma, squamous cell carcinoma) were reported during the 12-week oral METAOD005 trial

This finding is particularly noteworthy given that some trials extended to 24 weeks of continuous exposure and included participants with obesity-related comorbidities who might be expected to have higher baseline health risks

Glucagon receptor activation drives hepatic glucose output and, critically, increases energy expenditure through thermogenesis

Clinical procedures This research protocol was approved by the Massachusetts General Hospital/Brigham and Womens Hospital institutional review board and the U.S