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These foam cells accumulate within the arterial intima, forming fatty streaksthe earliest visible lesions of atherosclerosis [70]

Y.1990Regulation and drug resistance mechanisms of mammalian ribonucleotide reductase, and the significance to DNA synthesis

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Similarly, the reduction in EGR1 and FOS suggests a potential mechanism for curbing death receptor signaling and activator protein-1 (AP-1)-mediated inflammation 67,68,69 , While the downregulation of MAP3K8 (TPL2) might modulate the balance between the TGF- -Activated Kinase 1 (TAK1)-NFB and ASK1-c-Jun N-terminal Kinase (JNK) pathways 70