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In the current study, there was no significant difference in GSH levels between CM, CM and normal rat groups

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In previous work, we have shown in mice that inhibitors selective for bacterial GUS alleviated SN-38 dose limiting diarrhoea and reduced the number of NSAID-induced small intestinal ulcers, further suggesting that GUS enzymes give rise to undesired GI side effects by reversing Phase II glucuronidation 17,18,19