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Reported outcomes include: Falling asleep faster Fewer nighttime wake-ups More vivid dreams (a sign of longer REM cycles) Improved mood, cognitive performance, and recovery MK-677 significantly enhanced REM and slow-wave sleep in both younger and elderly subjects, suggesting therapeutic potential for sleep disorders and age-related GH decline. Van Cauter et al., Sleep 5

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siRNA transfection For Hk2 knockdown, the following siRNA sequences were employed: si Hk2 #1 (5-GCGACATTTATAGGTGGAGAA-3), si Hk2 #2 (5-CATCACCCTGCTGGTTCTAAA-3)