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The hormone hepcidin, elevated in chronic inflammation, binds to ferroportin inducing its internalization and degradation, thereby trapping iron within cells such as macrophages and potentiating pro-ferroptotic microenvironments ( In summary, ferroptosis is profoundly influenced by iron regulatory mechanisms centered on IRP/IRE signaling and ferritinophagy

Thiopurines are indicated as steroid-sparing maintenance agents in both Crohns disease and ulcerative colitis, but not as induction agents due to their slow onset of action [26]

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