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Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism

Interestingly, aerobic glycolysis, which corresponds to the fraction of glycolysis not coupled to oxidative phosphorylation and which was previously associated with biosynthetic and neuroprotective roles, was found to be reduced in brain regions with higher levels of Tau deposition (50)

[DOI] [PubMed] [Google Scholar] 22.Leungwattanakij S, Flynn V, Jr, Hellstrom WJ

Most of the existing studies have focused on the regulation of core molecules of the AMPK pathway (such as ACC, mTOR, and SEBP-1C), but its interaction with other metabolic pathways (such as PI3K/Akt, FGF21, and the gut microbiota-liver axis) has not been fully clarified, which limits the comprehensive understanding of the complex regulatory network in NAFLD