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256 Another study revealed elevated levels of p53 and proapoptotic proteins, including caspase-3, caspase-8, Bax, and Fas, in spinal motor neurons from individuals with ALS, whereas p53 levels were not altered in neurons of the motor cortex

In accordance with this, it has been estimated that the steady-state concentration of superoxide in the mitochondrial matrix is 5- to 10- fold higher than in the cytosol (Orrenius et al., 2007)

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