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Oxidative stress is a major cause in aging skin that causes wrinkles, hyperpigmentation and delayed wound healing ability

In parallel, studies have reported modulation of early growth response-1 (EGR-1) expression and its regulatory partner NAB2, which are involved in cytokine signaling and early extracellular matrix formation during cellular response processes [2]

However, Wang et al (56) demonstrated that lifelong aerobic exercise mitigates oxidative stress in aging skeletal muscle by activating the Keap1/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, thereby enhancing antioxidant enzyme activity

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