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Both effects were associated with mitochondrial biogenesis and the maintenance of calcium homeostasis 43,44

For example, stearoyl-CoA desaturase 1 suppresses autophagy by tuning lipid peroxidation and the mTOR pathway, thereby promoting NSCLC proliferation and metastasis (72)

On the contrary, in vivo , elevated H 2 S levels induced by some donors (NaHS, Na 2 S) can damage BTB integrity, decrease BTB-related gene expression rates, reduce testosterone levels, damage seminiferous tubules, and increase p38 MAPK phosphorylation, a signaling pathway, which regulates cell proliferation, differentiation, apoptosis, and stress response (85)

Glutamine sensitivity analysis identifies the xct antiporter as a common triple-negative breast tumor therapeutic target