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In addition, Activator Protein-1 (AP-1) and Nuclear Factor kappa-light-chain-enhancer of activated B-cells (NF-B) are key transcription factors highly responsive to ROS and RNS

Alisma orientalis beverage treats atherosclerosis by regulating gut microbiota in ApoE(-/-) Mice

The results exhibited that Fer-1 treatment inhibited the PA-induced iron deposition and steatosis and reduced the levels of IL-6, TNF-, Collagen I and -SMA expression in primary hepatocytes

Sustained or repeated fluxes saturate local peroxiredoxins and glutathione pools, spill into iron-rich chromatin niches and bias toward ONOO and Fenton chemistry that disrupt transcription