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In agreement to this, compounds derived from the propargyl ester derivatives and extended by azide-alkyne cycloaddition or Sonogashira coupling showed notable differences in JNK isoform specificity (measured for JNK2a2, JNK1b1 and JNK3a1, referred to below as JNK1, JNK2 and JNK3, respectively) (Supplementary Fig