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This phenomenon not only exists in glucose metabolism, but also in glutamine metabolism, where the level of glutamine in MET-induced tumors is nearly doubled, and further research has found that glutamine catabolic metabolism is increased in MYC-induced tumors, while glutamine synthesis is increased in MET-induced tumors (83)

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Berberine chloride (dual topoisomerase I and II inhibitor) modulate mitochondrial uncoupling protein (UCP1) in molecular docking and dynamic with in-vitro cytotoxic and mitochondrial ATP production

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