glutathione sulfhydryl transferase Disulfide - an overview Overexpression of Glutathione S-Transferases in

They populate the entire brain parenchyma with a homogeneous distributed network with territorial organization and act as the first and only line of defense in the brain

[,] Moreover, GSH plays a major role in protecting important cell constituents from the destruction caused by ROS such as free radicals, peroxides, and lipid peroxides

Campbell, Delivery of kinesin spindle protein targeting siRNA in solid lipid nanoparticles to cellular models of tumor vasculature

The Y296 residue has been demonstrated to be involved in a conformational change that occurs with NADPH binding (Silvestri et al., 2018), therefore the mutation of this residue was designed to perturb both formation of the NADPHSmTGR complex and FAD reduction