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10.3389/fcvm.2022.906753 26

Lipid Peroxidation in Neurodegeneration

Increased glucose uptake (through GLUT-1 induction) and glycolysis are hallmarks of HIV infection in CD4 + T-cells and MOs (Hollenbaugh et al., 2011

Among these, PTEN loss is particularly consequential, as it leads to dysregulation of the PI3K/AKT pathway, promoting unchecked cell growth and therapy resistance