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TABLE 525 Reactions of Importance in Relation to Oxidative Stress in Blood Cells and Various Tissues Superoxide is formed (reaction 1) in the red blood cell by the auto-oxidation of hemoglobin to methemoglobin (approximately 3% of hemoglobin in human red blood cells has been calculated to auto-oxidize per day)

Similarly, previous studies demonstrated that VPA treatment lowered FA levels by blocking the reuptake of folic acid, leading to a 25%35% decrease in FA levels ( 12 were also decreased in ABLF patients than NLF patients ( p = 0.022)

At this condition, body cannot detoxify itself over long periods and the ROS keeps on increasing continuously, leading to an oxidative stress condition