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Previous studies have reported that overexpression of SARD1 can control SA synthesis by regulating ICS1 at the transcriptional level, thereby activating defense responses (Zhang Y

A prospective randomized controlled open trial of 75 breast cancer patients showed that oral NAC (1200 mg once and twice daily) was effective in reducing the incidence and severity of paclitaxel-induced peripheral neuropathy, accompanied by increased serum nerve growth factor (NGF) levels and decreased malondialdehyde (MDA) levels, which could prevent grade 3 neurotoxicity [68]

For example, functional imaging studies have revealed hyperactivity in the PAG, thalamus, ACC, and somatosensory cortex in individuals experiencing taxane-induced peripheral neuropathy (80)