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Itaconate also dampens NLRP3 activity after prolonged LPS exposure, playing an important role in the resolution of inflammation [117], and suppression of itaconate can contribute to chronic inflammation

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In more severe cases, when conservative treatments are insufficient, biologic injections or surgery may be considered as alternative options

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a 31% increase in a product of lipid oxidation (MDA) and a 447% increase in a product of protein oxidation (protein carbonyl)] 47

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