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In preeclamptic patients, there is a relative disorder in the gut microbiota, such as a decrease in the abundance of Firmicutes and an increase in the abundance of Proteobacteria

In this context, although while studies conducted in meta-analyses suggest that a consistent circadian rhythm is not observed, possibly due to small sample sizes, a recent study reported that sphingolipids and phospholipids exhibit higher concentrations in the evenings, with diacylglycerols and triacylglycerols showing more pronounced circadian variation compared to phospholipids and sphingolipids [3, 33]

Highly oxidative organs such as the heart, liver, and brain are particularly vulnerable to pathogen-induced mitochondrial dysfunction due to their dependence on oxidative phosphorylation

Cell 153 , 840854 (2013)