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Functionalized siRNA-chitosan nanoformulations promote triple-negative breast cancer cell death via blocking the miRNA-21/AKT/ERK signaling axis: in-silico and in vitro studies

doi: 10.1177/0891988713500587 42 SohrabjiF

In fact, polylysine at alkaline pH and polyglutamic acid at acid pH form -helical conformations, since under these conditions they have neutral side chains, whereas at high pH and high temperature, polylysine adopts an extended, flat, multistranded -sheet conformation, and polyglutamic acid forms -sheet structure at low pH

5 Summary In summary, this perspective analyses anesthesias role in POCD pathogenesis through the unifying two-hit model, wherein perioperative insults amplify pre-existing neural vulnerability