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Using the enzymatic characteristics of NQO1, a variety of NQO1-activated optical probes for imaging different cells in various tissues, including the brain, have been developed [279]

As of mid-2026, none of these peptides has completed the clinical trials required to become an approved drug

We used four criteria for estimation of the edema: a pale myelin, sieve-like appearance of myelinated areas, dilation of perivascular and pericellular spaces and vacuolar appearance of the neuropil of gray matter

It should be mentioned that not only EBV infection has been linked to ME/CFS, but also human herpesvirus (HHV)-6, cytomegalovirus (CMV), human parvovirus B19, and enteroviruses [22, 23, 28, 163168], as well as bacterial and parasitic infections [169]