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Striatal D1-D3R heteromers are closely correlated with age of onset, PD stage, dopamine responsiveness, and survival time ( via activating D1R/Shp-2/Erk1/2 pathway ( Chronic administration of the histamine H3 receptor agonist immepip decreases L-Dopa-induced dyskinesias ( NMDAR antagonist MK-801 aggravates D1R-induced dyskinesias, while effectively reduces D2R-induced dyskinesias, the degree of which is of the same magnitude as the reduction of L-DOPA-induced dyskinesias ( There is an increase in the therapeutic index and locomotor improvement of L-DOPA with adenosine A2AR antagonists, like istradefylline ( In addition, simultaneous blockade of both mGlu5 and A2AR in A2AmGlu5-D2R RM increases their efficacy in reversing parkinsonian deficits ( Hippocampus DRs are widely expressed in the hippocampus