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doi: 10.3389/fimmu.2024.1346656 Received 29 November 2023 Accepted 29 January 2024 Published 20 February 2024 Volume 15 - 2024 Edited by Saikolappan Sankaralingam, AIM Laboratories, United States Reviewed by Nicoletta Sorvillo, Takeda Development Centers Americas, United States Updates Copyright 2024 Kannan and Girija A.S

Regarding neuroplasticity regulation, suppressed Notch/DNER signaling and dysregulated Wnt/AXIN1 pathway may compromise hippocampal neurogenesis [26, 53, 54], while disrupted NTRK2-BDNF signaling and impaired Nr-CAM-mediated cell adhesion could lead to decreased synaptophysin synthesis and dendritic complexity [55]

However, much of the evidence remains associative and the extent to which ferroptosis precedes or follows cartilage matrix degradation is not yet fully defined