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Epigenetic regulation: mitochondrial metabolites and nuclear chromatin state coupling Mitochondrial metabolites serve dual roles in energy production and epigenetic regulation, directly influencing nuclear chromatin states and modulating ovarian physiology through dynamic regulation of gene transcription

The primary obstacle to widespread adoption of this approach is the substantial research and development expenses, along with the potential high costs involved in bringing it to market (257)

It leads to S phase arrest in colon cancer cells [232,233,234]

There are extensive reviews indicating that chronic or binge consumption of alcohol by pregnant women can significantly lower the availability of important micronutrients such as folate and choline at a time when the developing brain of the fetus is vulnerable to environmental changes (Ernst et al , 2022