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Residing in the BMME allows LSCs to adapt their metabolic profile, evade chemotherapy and drive disease relapse

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ZIP7 is situated in the Golgi apparatus and ER, while ZIP13, evolutionarily closest to ZIP7, is localized in the Golgi apparatus and cytoplasmic vesicles

Solving this dilemma requires the development of precision targeting strategies, such as nanomedicine delivery systems based on surface markers of B cell subsets (such as CD10 and MUM1), which can achieve selective drug delivery by targeting specific surface antigens on tumor-associated B cells, thereby reducing damage to normal B cell subsets (169)