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In principle, sphingomyelin can be hydrolyzed by different enzymes: neutral SMase, acidic SMase, and secreted forms of SMases [120]

Assay, purification, and characterization of cobaltochelatase, a unique complex enzyme catalyzing cobalt insertion in hydrogenobyrinic acid a,c-diamide during coenzyme B 12 biosynthesis in Pseudomonas denitrificans

Rats that lost the majority of their orexinergic neurons exhibited multiple SOREMPs as well as less wakefulness during nocturnal hours, shortened REM latency, and brief periods of cataplexy

Toxicity studies confirm good biocompatibility, with no cytotoxicity up to 200 g/mL and no pathological changes in major organs (191)